WebSep 9, 2024 · We found that FTH1 protein was upregulated in all resistant cell lines after 72 hrs from 6 Gy exposure, as reported in Figure 3A,B. Moreover, H460 and MCF7, sorted on the basis of their LD content, were characterized by an increase in the mRNA level of FTH1 in the LD high subpopulation compared to the LD low cells ( Figure 3C ). This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multipl…
Entry - *134770 - FERRITIN HEAVY CHAIN 1; FTH1 - OMIM
WebFerritin heavy chain 1. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. FTH1 (FHC, FTH, FTHL6, PIG15, PLIF) Protein … WebNov 12, 2015 · FTH1 functions as a major iron storage protein and TFRC regulates iron entry into cells. Therefore, p53-ISCU pathway would play an important role in the maintenance of iron homeostasis. Full size ... decogao マスク
Ferritin heavy/light chain (FTH1/FTL) expression, serum ... - PubMed
WebFeb 1, 2024 · As shown in Fig. 2, the protein levels of FTH1 and FTL are higher in NRF2- KO cells , despite lower FTH1 and FTL mRNA levels , which may be due to the fact that the formation of the ferritin complex is primarily controlled by the UPS (HERC2, FBXL5, NCOA4, and IRP1/2), lysosomal degradation (FTH1, FTL, and NCOA4), and protein synthesis … WebJun 14, 2016 · NM_002032.3(FTH1):c.*389A>G Genes: BEST1:bestrophin 1 [Gene - OMIM - HGNC] FTH1:ferritin heavy chain 1 [Gene - OMIM - HGNC] Variant type: single nucleotide variant Cytogenetic location: 11q12.3 Genomic location: Chr11: 61964338 (on Assembly GRCh38) Chr11: 61731810 (on Assembly GRCh37) Preferred name: WebNov 12, 2015 · Knockdown of ISCU enhanced the binding of iron regulatory protein 1 (IRP1), a cytosolic Fe-S protein, to an iron-responsive element in the 5' UTR of ferritin heavy polypeptide 1 (FTH1) mRNA and subsequently reduced the translation of FTH1, a major iron storage protein. decodefile は 指定されたファイルが見つかりません。